What Is Benefix?

Prothromboplastin beta (english: beta prothromboplastin, christmas issue, plasma thromboplastin element, ptc, antihemophilic issue b, antihemophilic globulin b, autoprothrombin ii, issue ix, repair, plasma issue x, plasma thromboplastin issue b, ptf-b, platelet cofactor ii )[1] is a sort of glycoprotein within the type of a single-chain serine protease synthesized by hepatocytes as a precursor protein which then undergoes posttranslational modification and turns into an entire zymogen earlier than being secreted into the blood circulation.

[2]. The plasma ratio of repair is about 4-5 g/ml with a half-life starting from 18-24 hours.

[2] repair deficiency will end in bleeding in muscle and joint tissue often called hemophilia sort b.

Fix injections are marketed underneath such names as: alphanine sd, bebulin vh, benefix, mononine, profilnine sd, proplex t.

[3].

What Is Benefix Used For?

BeneFIX works by changing issue IX to allow blood to clot. BeneFIX is used for the management and remedy of bleeding and the prevention of bleeding in folks with haemophilia B.

How Does Benefix Work?

BeneFIX works by changing issue IX in haemophilia B sufferers to allow their blood to clot. BeneFIX is used for the remedy and prevention of bleeding in sufferers with haemophilia B (congenital issue IX deficiency) in all age teams.

What Is Benefix Made Of?

BeneFIX will not be derived from human blood. It is produced by a genetically engineered Chinese hamster ovary (CHO) cell line that’s extensively characterised. No components of animal or human origin are used in the course of the cell tradition, purification, and formulation processes of BeneFIX.

How Do You Administer Benefix?

BeneFIX is run by intravenous infusion after reconstitution of the lyophilised powder for resolution for injection with sterile 0.234% sodium chloride resolution (see part 6.6). BeneFIX must be administered at a gradual infusion charge. In many of the instances, an infusion charge of as much as 4 mL per minute has been used.

What Is Recombinant Factor Ix?

Recombinant Coagulation Factor IX is a purified Factor IX glycoprotein produced by recombinant DNA expertise. It has a major amino acid sequence that’s similar to the Ala148 allelic type of human issue IX, and has structural and useful traits just like these of endogenous issue IX.

How Is Benefix Given?

BeneFIX is run by intravenous infusion after reconstitution of the lyophilised powder for resolution for injection with sterile 0.234% sodium chloride resolution (see part 6.6). BeneFIX must be administered at a gradual infusion charge. In many of the instances, an infusion charge of as much as 4 mL per minute has been used.

Is Benefix A Blood Product?

Indication: BeneFIX is a recombinant human blood coagulation issue IX indicated for the remedy of: Adults and kids with hemophilia B (congenital issue IX deficiency or Christmas illness) for: On-demand remedy and management of bleeding episodes.

Who Makes Benefix?

for Health Care Professionals: BENEFIX U.S. Physician Prescribing Information. BENEFIX U.S. Medical Information Page – scientific & security data, methods to contact Pfizer Medical & different sources.

How Long Does Benefix Last?

Every 24 hours, a minimum of 1 day, till therapeutic is achieved. BeneFIX could also be administered for long run prophylaxis towards bleeding in sufferers with haemophilia B.

How To Reconstitute Benefix?

BeneFIX is equipped as a powder. Before it may be infused in your vein (intravenous injection), you could reconstitute the powder by mixing it with the liquid diluent equipped. The liquid diluent is 0.234% sodium chloride.

How Is Factor 9 Administered?

Factor IX is usually administered as a gradual IV push (bolus injection). Continuous infusion of Factor IX is indicated for sufferers requiring admission for extreme bleeds or surgical procedures. Factor IX substitute for such sufferers must be managed in session with Clinical Haematology.

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